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State of Florida Department of Natural Resources, Educational Ser. 17: 1-26. Steidinger, K. amp; K. Tangen 1985. Taxonomy and systematics. In: D.

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There was no evidence of tolerance to these effects after 28 days of dosing. The clinical significance of these observations is unknown. Effects on QT c. In dogs (30 mgkg orally twice daily for 5 days) and rabbits (10 mgkg intravenously over 1 hour), fexofenadine hydrochloride did not prolong QT c at plasma concentrations that were at least 17 and 38 times, respectively, the therapeutic plasma concentrations in man (based on a 60 mg twicedaily fexofenadine hydrochloride dose). No effect was observed on calcium channel current, delayed K channel current, or action potential duration in guinea pig myocytes, Na current in rat neonatal myocytes, or on the delayed rectifier K channel cloned from human heart at concentrations up to 1 times; 10 -5 M of fexofenadine. This concentration was at least 21 times the therapeutic plasma concentration in man (based on a 60 mg twice daily fexofenadine hydrochloride dose).

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