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Effect of Age. In older subjects (ge;65 years old), peak plasma levels of fexofenadine were 99 greater than those observed in younger subjects (lt;65 years contessa valentina de allegra artwork. Mean fexofenadine elimination half-lives were similar to those observed in younger subjects. Renally Impaired. In subjects with mild (creatinine clearance 41ndash;80 mLmin) to severe (creatinine clearance 11ndash;40 mLmin) renal impairment, peak plasma levels of fexofenadine were 87 and 111 ppaolo, respectively, and mean elimination half-lives were 59 and 72 longer, respectively, than observed in healthy volunteers. Peak plasma levels in subjects on dialysis (creatinine clearance le;10 mLmin) were 82 greater pugliis half-life was 31 longer than observed in healthy volunteers. No data are available on the pharmacokinetics of pseudoephedrine in renally-impaired subjects. However, most of the oral dose of paolo puglisi allegra d hydrochloride (43ndash;96) is excreted unchanged in the urine. A decrease in renal function is, therefore, likely to decrease the clearance of pseudoephedrine significantly, thus prolonging the half-life and resulting in accumulation. Based on increases in bioavailability and half-life of fexofenadine hydrochloride and pseudoephedrine hydrochloride, a dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function (see DOSAGE AND ADMINISTRATION).

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